I came across this product, listened to an expert talking about how Klotho reduces kidney oxidative stress and urinary protein levels, and decided to give it a try. A few days later, I noticed a significant difference when I slept. If you know what I mean, hardly getting up at night to use the bathroom might seem normal to others, but for me, it's rare. And a few days after that, I noticed a reduction in pain! That's exactly what I was hoping for. This product is great on many levels... I'm seeing a lot of benefits. I appreciate the fact that it's the most effective treatment.